In a bowl, soak the chicken tenders in buttermilk for at least 30 minutes.
In another bowl, mix the flour, salt, pepper, garlic powder, onion powder, and smoked paprika.
In a separate bowl, whisk the egg.
In a third bowl, combine the breadcrumbs and Parmesan cheese.
Dredge each tender in the flour mixture, dip into the egg, then coat with the breadcrumb mixture.
Heat oil in a pan to 350°F (175°C).
Fry the tenders in batches for about 3-4 minutes per side until golden brown and fully cooked.
Drain on paper towels and serve with your favorite dipping sauce.