Boil a large pot of water and cook macaroni until just shy of al dente. Drain and set aside.
In the same pot, melt butter over medium heat. Whisk in flour and cook for 1 minute.
Slowly add heavy cream and milk, whisking constantly until smooth.
Season with salt, pepper, garlic powder, and onion powder.
Reduce heat to low and stir in all three cheeses until melted and velvety.
Add cooked macaroni back into the pot and stir to coat. Let simmer for 1–2 minutes.
Serve hot and prepare to fight off the urge to eat the entire pot yourself.